Putative functions of nucleoside diphosphate kinase in plants and fungi. 1999 Jul 9;274(28):19630-8 MyBioSource.com. The E. coli NDP kinase was found to consist of 143 amino acid residues that are 57, 45, 45, 42, 43, and 43% identical to the M. xanthus, Dictyostelium discoideum, Drosophila melanogaster, mouse, rat, and human enzymes, respectively. Perina D, Korolija M, Miko A, Halasz M, Herak Bosnar M, etkovi H. Mar Drugs. MeSH Evidence for a novel gene associated with low tumor metastatic potential. Two transcript variants encoding different isoforms have been found for this gene. It occurs at different but precise mitochondrial locations and can affect among other mitochondrial shapes and dynamics, as well as the specific elimination of defective mitochondria or cells via mitophagy or apoptosis. The .gov means its official. Academic Press, Cambridge, pp 307333, Reumann S, Quan S, Aung K, Yang P, Manandhar-Shrestha K, Holbrook D, Linka N, Switzenberg R, Wilkerson CG, Weber APM, Olsen LJ, Hu J (2009) In-depth proteome analysis of Arabidopsis leaf peroxisomes combined with in vivo subcellular targeting verification indicates novel metabolic and regulatory functions of peroxisomes. PMC official website and that any information you provide is encrypted These data support a model in which NM23/NDP kinase modulates gene expression through DNA binding and subsequent structural transactions. 2019 Dec 6;202(1):e00567-19. FEBS Lett. In the first group, one of the genes named NM23 was identified as the first metastasis suppressor protein and its gene Nm23 was less activated in metastatic cells. Cell 143(4):606616, Veljovic-Jovanovic S, Noctor G, Foyer CH (2002) Are leaf hydrogen peroxide concentrations commonly overestimated? Among its related pathways are Pyrimidine metabolism and Metabolism of nucleotides . Biochem J. Lab Invest 98, 582588 (2018). [72]). J Biol Chem. Combinatorial chemistry Biochemistry Stereochemistry Hydrolysis Gene Prodrug Nucleoside-diphosphate kinase Enzyme Chemistry Nucleotide Nucleoside triphosphate Nucleoside Nucleoside analogue Christoph R. Meier, Henning J. Jessen, Tilmann Schulz, Lina Weinschenk, Florian Pertenbreiter, Jan Balzarini Its expression and subcellular localization were examined. This property is shared by the cytosolic NME1/2 acting on dynamin 1/2 in endocytosis [16]. The ability of Nm23-H2 to activate c-MYC transcription in vitro and in vivo via the same element demonstrates the biological significance of this interaction. PubMed Central Amutha B, Pain D. Nucleoside diphosphate kinase of Saccharomyces cerevisiae, Ynk1p: localization to the mitochondrial intermembrane space. 2003;555:3636. Nucleoside diphosphate kinases (NDPKs) are highly conserved enzymes ubiquitously found in various organisms from bacteria to human. Adaptation; Bacteria; Bacteria and host interactions; Nucleoside diphosphate kinase; Nucleotide metabolism; Virulence. Hum Mol Genet. Clin Exp Metastasis 19(6):465476, Rika K, Ljung K, Vanneste S, Podhorsk R, Beeckman T, Friml J, Benkov E (2007) Ethylene regulates root growth through effects on auxin biosynthesis and transport-dependent auxin distribution. Mitochondrial NDPK activity was mostly located outside the matrix in pigeon heart, as well as mammalian liver [5]. You can help Wikipedia by expanding it. NME/NM23 nucleoside diphosphate kinase 6 Synonyms nm23-M6, non-metastatic cells 6, protein expressed in (nucleoside-diphosphate kinase) Feature Type protein coding gene IDs MGI:1861676 NCBI Gene: 54369 Alliance gene page Transcription Start Sites 6 TSS Location & Maps more Sequence Map Chr9:109661788-109672042 bp, + strand This enzyme belongs to the family of transferases, specifically those transferring two phosphorus-containing groups (diphosphotransferases). The binding mode of human nucleoside diphosphate kinase B to single-strand DNA. [47] recently demonstrated that NDPK-D/NME4 is required for mitophagy induced by different mitophagic stimuli in murine lung epithelial MLE-12, SH-SY5Y, and HeLa cells. Before Xu ZY, Chen JS, Shu YQ. 1991 Jan 1;51(1):445-9 Learn more about Institutional subscriptions, Ahsan N, Lee DG, Lee KW, Alam I, Lee SH, Bahk JD, Lee BH (2008) Glyphosate-induced oxidative stress in rice leaves revealed by proteomic approach. Google Scholar. Correspondence to Mitochondrial dynamics regulates migration and invasion of breast cancer cells. Plant Physiol 122(2):447452, Parks RE, Aganwal RP (1973) 9 nucleoside diphosphokinases. Epub 2013 Oct 28. Mol Cell Biochem 329(1):315, Miao Y, Jiang L (2007) Transient expression of fluorescent fusion proteins in protoplasts of suspension cultured cells. Nat Cell Biol. Genomics. Other gene names. P.O. Oncogene. Mutational analyses have identified Arg34, Asn69 and Lys135 as critical for DNA binding, but not required for the NDP kinase reaction. CAS In humans, the only NDPK possessing a typical N-terminal mitochondrial targeting sequence is NDPK-D/NME4 encoded by the NME4 gene located on the short arm of chromosome 16 at 16p13.3, in the same region as NME3 [12, 13]. In the meantime, to ensure continued support, we are displaying the site without styles CYTOPLASMIC. Plant Cell Physiol 46(8):12461254, Ding WN, Lin L, Zhang BT, Xiang XB, Wu J, Pan ZC, Zhu SH (2015) OsKASI, a -ketoacyl-[acyl carrier protein] synthase I, is involved in root development in rice (Oryza sativa L.). The protein can be with or without a His-Tag or other tag in accordance to customer's request. Nucleoside diphosphate kinase A (NDPK-A), encoded by the nm23-H1 gene, acts as a metastasis suppressor . In addition to this, plants have four types of NDPK isoforms. The authors declare that they have no conflict of interest. Thank you for visiting nature.com. Cell Rep. 2014;8:75466. However, consumption of ATP would definitely influence the cellular energy balance, which brings upon the regulation of AMP-activated protein kinase (AMPK). Part of Springer Nature. FEBS Lett. 2004 Mar;37(6):914-39 Overexpression of Phosphoribosyl Pyrophosphate Synthase Enhances Resistance of. Nme2, one of the NDPK genes, has been associated with cardiovascular functions. sharing sensitive information, make sure youre on a federal Disclaimer. PubMed Central [1] Other activities include cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor, endocytosis, and gene expression. Negroni A, Venturelli D, Tanno B, et al. The results provide the first evidence that NDPK-A behaves as a metastasis promoter at least in human neuroblastoma derived from NB69 cells and suggest a prognostic value of NDPk-A in neuroblastomas patients but also caution NDPK -A-targeted treatment for patients with different tumor types. Mitochondrial nucleoside diphosphate kinase (NDPK-D; synonyms: NME4, NM23-H4) represents the major mitochondrial NDP kinase. The human nm23-H4 gene product is a mitochondrial nucleoside diphosphate kinase. Because of such activity, AMPK could directly inhibit NDPK through phosphorylation. Qin QP, Meng T, Tan MX, Liu YC, Wang SL, Zou BQ, Liang H. Medchemcomm. J Cell Sci. Jin Ye and Wona Ding contributed equally to this paper. PMC Epub 2018 Feb 7. Acta Chem Scand 25(4):13701376, Fatehi F, Hosseinzadeh A, Alizadeh H, Brimavandi T (2013) The proteome response of Hordeum spontaneum to salinity stress. PubMed PLoS ONE. Known unknowns of cardiolipin signaling: The best is yet to come. The aim of this study was to elucidate the function of OsNDPK4 in rice. Such motifs can be also found in other CL-interacting proteins such as cytochrome c [41] and mitochondrial creatine kinase (mtCK) [42]. doi: 10.1111/cmi.12825. oryzae infection via reducing H3K4me2/3 associated with negative disease resistance regulators. NM23-H2/NDP kinase B has been identified as a sequence-specific DNA-binding protein with affinity for a nuclease-hypersensitive element of the c-MYC gene promoter (Postel et al., 1993). J Bioenerg Biomembr. Annotation score. Dual function of mitochondrial Nm23-H4 protein in phosphotransfer and intermembrane lipid transfer: a cardiolipin-dependent switch. NME4 belongs to the group I members of the NDPK/NME family which can be divided in two groups in mammals, based on phylogenetic analyses [20, 21]. The protein can be with or without a His-Tag or other tag in accordance to customer's request. 2003 Feb;35(1):57-65. doi: 10.1023/a:1023493823368. NDPK has also been discovered to act as a protein histidine kinase, which involves a reversible histidine phosphorylation as a well-known regulatory signal. J Biol Chem. Accessibility When Nme2 gene products were over-produced in gastric cancer cells, there was a decrease in proliferation, migration, and invasion of such cancer cells. Xiong L, Yi F, Yu Q, Huang X, Ao K, Wang Y, Xie Y. BMC Microbiol. Provided by the Springer Nature SharedIt content-sharing initiative, Molecular and Cellular Biochemistry (2020), Laboratory Investigation (Lab Invest) Gene ID: 4833, updated on 5-Aug-2022 Summary The nucleoside diphosphate (NDP) kinases (EC 2.7.4.6) are ubiquitous enzymes that catalyze transfer of gamma-phosphates, via a phosphohistidine intermediate, between nucleoside and dioxynucleoside tri- and diphosphates. Box 153308 San Diego, California. Two other human genes, NME3 (encoding NDPK-C) and NME6, encode proteins that have been reported to be, at least partly, located to mitochondria [14,15,16]. PubMed government site. Nucleoside diphosphate kinase (NDK), a ubiquitous enzyme, catalyses reversible transfer of the phosphate from nucleoside triphosphates to nucleoside diphosphates and functions to maintain the pools of ribonucleotides and deoxyribonucleotides in the cell. It is also part of the neural development process, which includes neural patterning and cell fate determination. Maguire JJ, Tyurina YY, Mohammadyani D, et al. These proteins go about interrupting metastasis by binding metastasis-promoting proteins. Plant J 89(5):914926, Edlund B (1971) Purification of a nucleoside diphosphate kinase from pea seed and phosphorylation of the enzyme with adenosine (32 p) triphosphate. J Biol Chem. 2002;13:44955. A nuclear localization of NME4 was recently reported and related to NME4 deacetylation via SIRT1 [32]. Zhang J, Nomura T, Yatsunami K, Honda A, Sugimoto Y, Moriwaki T, Yamamoto J, Ohta M, Fukui T, Ichikawa A. Biochim Biophys Acta. Further, it supports the concept of NME proteins being part of complexes responsible for channeling NTP for specific cellular processes [48]. The transcriptomic change in roots of Osndpk4 was analyzed by RNA-seq. Genes Dev. the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Read More Seifert M, Welter C, Mehraein Y, Seitz G. Expression of the nm23 homologues nm23-H4, nm23-H6, and nm23-H7 in human gastric and colon cancer. Import of lipids into mitochondria. Lacombe, ML., Tokarska-Schlattner, M., Boissan, M. et al. A dysfunctional rice mutant was employed to characterize the function of OsNDPK4. NDPK activities maintain an equilibrium between the concentrations of different nucleoside triphosphates such as, for example, when guanosine triphosphate (GTP) produced in the citric acid (Krebs) cycle is converted to adenosine triphosphate (ATP). Separate nuclear genes encode cytosolic and mitochondrial nucleoside diphosphate kinase in Dictyostelium discoideum. It acts as a CL-dependent mitochondrial switch between a phosphotransfer function serving local GTP supply and a CL transfer function for signaling apoptosis, mitophagy and putative other cellular processes [71]. NDPK-D/NME4 was shown to inhibit anchorage-independent growth but not motility of the highly metastatic MDA-MB435 and MDA-MB231 human cell lines [65]. Bethesda, MD 20894, Web Policies Disclaimer. OsNDPK4 was found to be expressed in a variety of tissues throughout the plant and OsNDPK4 was located in the cytosol. David Molina-Granada, Emiliano Gonzlez-Vioque, Ramon Mart, Nikolaus Pfanner, Bettina Warscheid & Nils Wiedemann, Marta Giacomello, Aswin Pyakurel, Luca Scorrano, Seiko Nakamura, Aiko Matsui, Toshihiko Oka, Wenjun Wang, Jianshuang Li, Qinghua Zhou, Zachary A. Kemmerer, Kyle P. Robinson, David J. Pagliarini, Laboratory Investigation The potential influence of artefactual interference by tissue phenolics and ascorbate. Federal government websites often end in .gov or .mil. Desvignes T, Pontarotti P, Fauvel C, Bobe J. Nme protein family evolutionary history, a vertebrate perspective. This review will provide a synopsis of the current knowledge regarding the biological properties and roles of Ndks in regulating bacterial virulence and adaptation and will discuss in depth the biological significance of Ndk during bacteria-host interactions. Disclaimer. 1999;76:25469. CL is synthesized and mainly located at the mitochondrial inner membrane. With its diphosphatidylglycerol structure exposing two negative charges, it could interact with pairs of adjacent basic residues of NDPK-D/NME4 (e.g., R89-R90) that are at a similar distance of about 510. Planta This requires the presence of CL in the membranes, and does not involve vesicle fusion or loss of the internal contents of the liposomes [50]. Cereal Res Commun 41(1):7887, Feng BH, Yang Y, Shi YF, Shen HC, Wang HM, Huang QN, Xu X, Lu XG, Wu JL (2013) Characterization and genetic analysis of a novel rice spotted-leaf mutant HM47 with broad-spectrum resistance to Xanthomonasoryzae pv. Saturation of all CL-binding sites with CL-containing liposomes totally inhibits NDP kinase activity [35], while partial saturation (i.e., the hexamer bound at only at one side to a membrane) only gradually reduces NDP kinase activity (unpublished). Careers. 2021 Aug;63(8):719-731. doi: 10.1007/s12033-021-00338-3. Quaternary structure of nucleoside diphosphate kinases. sharing sensitive information, make sure youre on a federal Nucleoside Diphosphate Kinase Escalates A-to-C Mutations in MutT-Deficient Strains of Escherichia coli. In: Boyer PD (ed) The enzymes, 8th edn. doi: 10.1073/pnas.2118852119. A similar CL externalization occurs under condition that favor mitophagy, the selective autophagic elimination of damaged mitochondria [55]. Mol Cancer 2014;13:218. and transmitted securely. PLoS Biol. 2013;32:481424. Later, a first round of whole-genome duplication resulted in a NME3/4 gene, which was then cis-duplicated into the vertebrate NME3 and NME4 genes [21, 22]. Mol Plant 8(4):495505, Yano A, Shimazaki T, Kato A, Umeda M, Uchimiya H (1993) Molecular cloning and nucleotide sequence cDNA encoding nucleoside diphosphate kinase of rice (Oryza sativa L.). These candidate genes included nm23, annexin I, protein phosphatase-1, ferritin, proteasome -6, N-acetyl glucosamine kinase (NAGK) and an A6-related protein. Its processes are involved with cell proliferation, differentiation and development, and gene expression in human cells. The mutated p53 gene (TP53) has been detected in approximately 50% of all human tumors, such as breast, brain, lung, . In plants [6, 7] and amoeba [8], a mitochondrial NDPK was localized in the intermembrane/cristae space. Hamilton HM, Wilson R, Blythe M, Nehring RB, Fonville NC, Louis EJ, Rosenberg SM. The human Nm23/nucleoside diphosphate kinases. volume251, Articlenumber:77 (2020) Besse A, Wu P, Bruni F, et al. A mitochondrial nucleoside diphosphate kinase (NDPK) activity was described already in 1955 [1], soon after the discovery of the enzyme. 2005;322:36578. 1997;36:10330. [16] The localization and exact function of the type IV NDPK is not yet well known and needs further investigations. JMJ704 positively regulates rice defense response against Xanthomonas oryzae pv. Barraud P, Amrein L, Dobremez E, et al. Plant Cell 13(4):889905, Kihara A, Saburi W, Wakuta S, Kim M-H, Hamada S, Ito H, Imai R, Matsui H (2011) Physiological and biochemical characterization of three nucleoside diphosphate kinase isozymes from rice (Oryzasativa L.). Federal government websites often end in .gov or .mil. The ability of Nm23-H2 to activate c-MYC transcription in vitro and in vivo via the same element demonstrates the biological significance of this interaction. Among its related pathways are purine nucleotides de novo biosynthesis and pyrimidine deoxyribonucleotides biosynthesis from CTP . T32-HL07343/HL/NHLBI NIH HHS/United States, NCI CPTC Antibody Characterization Program, Annu Rev Biophys Biomol Struct. 2000 Jun;32(3):285-92. doi: 10.1023/a:1005593130867. Language links are at the top of the page across from the title. Anticancer Res. 2006;87:4839. Some further findings support a dual mitochondrial localization of NDPK-D/NME4 in the matrix: it is found associated with the matrix enzyme succinyl-CoA synthetase [44] and mitoribosomes [45], and physically interacts with a transaminase (ABAT) of the mitochondrial nucleoside salvage pathway, leading to mtDNA depletion syndrome when mutated [46]. 1989;981:21325. United States Phone: 215-583-7898 Nme1 and Nme2 as a suppressor of metastasis, "PDB 1jxv structure summary Protein Data Bank in Europe (PDBe) EMBL-EBI", "Nucleoside diphosphate kinase (IPR001564)", "X-ray structure of nucleoside diphosphate kinase", "NME1 - Nucleoside diphosphate kinase A - Homo sapiens (Human) - NME1 gene & protein", "Increased activity of membrane-associated nucleoside diphosphate kinase and inhibition of cAMP synthesis in failing human myocardium", "AMPK directly inhibits NDPK through a phosphoserine switch to maintain cellular homeostasis", "spoT - Bifunctional (p)ppGpp synthase/hydrolase SpoT - Escherichia coli (strain K12) - spoT gene & protein", "G proteins: more than transducers of receptor-generated signals? 2014;100:21926. Name. Mitochondrial dynamics protein Drp1 is overexpressed in oncocytic thyroid tumors and regulates cancer cell migration. This is a preview of subscription content, access via your institution. Moreover, both NM23-H1 and Nm23-H2 bind to nuclease hypersensitive elements in the platelet-derived growth factor PDGF-A gene promoter sequence-specifically, correlating with either positive or negative transcriptional regulation. NME1 Antibody (OTI6A11), TA801313, from Invitrogen. Prog Lipid Res. However, no specific mitochondrial targeting sequence could be detected in these proteins, although NDPK-C/NME3 possesses a N-terminal hydrophobic peptide (17 amino acids), which could anchor the protein to membranes [17, 18]. [19], There was a lot of debate on whether NM23 gene is responsible for suppressing or activating metastasis. Plant Mol Biol 64(1):205217, Wasternack C, Hause B (2013) Jasmonates: BIOSYNTHESIS, perception, signal transduction and action in plant stress response, growth and development. 1993;129:1416. Nucleoside diphosphate kinase homolog 5 Short names NDK-H 5; NDP kinase homolog 5 Alternative names Inhibitor of p53-induced apoptosis-beta ( IPIA-beta) Testis-specific nm23 homolog nm23-H5 Gene names Name NME5 Organism names Organism Homo sapiens (Human) Taxonomic identifier 9606 NCBI Taxonomic lineage Plant Dis Rep 57:537541, Kawasaki S, Borchert C, Deyholos M, Wang H, Brazille S, Kawai K, Galbraith D, Bohnert HJ (2001) Gene expression profiles during the initial phase of salt stress in rice. Plant Cell Physiol. Cell Death Differ. We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. Clipboard, Search History, and several other advanced features are temporarily unavailable. Schlattner U, Tokarska-Schlattner M, Ramirez S, et al. A basic residue equivalent to R90 can be found in NDPK-D/NME4 ortholog sequences from mammals, fish, and Xenopus, as well as, curiously, in mitochondrial NDPK from Dictyostelium discoideum but not in the mitochondrial NDPK of birds and of lower organisms such as Drosophila, Caenorhabditis elegans, and bacteria [34]. Osndpk4 showed enhanced resistance to the bacterial pathogen Xanthomonas oryzae pv. S129 evolved only more recently, since teleost NDPK-D/NME4s still possess a proline at this position, the serine appearing only in tetrapods after the sarcopterygian radiation [21]. Functional cloning of a nucleoside diphosphate kinase from Dictyostelium discoideum. When there is an absence of a charged tRNA in the A site of a ribosome, the ribosome will stall and trigger the synthesis of the guanosine pentaphosphate ((p)ppGpp) molecule. Rytomaa M, Kinnunen PK. Please enable it to take advantage of the complete set of features! Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by this gene) and 'B' (encoded by NME2) isoforms. Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Recent studies have identified polymorphisms in NUDT15 that are associated with toxicities of thiopurines. In oral cancer, miR-196 was highly overexpressed in cancer tissue and correlated with lymph node metastasis. [supplied by OMIM, Jul 2010] Before The other group genes code for other various proteins that display low or no NDPK activities. 2010;64:1339. https://doi.org/10.1007/s00425-020-03355-9, DOI: https://doi.org/10.1007/s00425-020-03355-9. Nucleoside diphosphate kinase Gene YNK1 Status UniProtKB reviewed (Swiss-Prot) Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) Amino acids 153 Protein existence Evidence at protein level Annotation score 5/5 Entry Feature viewer Publications External links History BLAST Add a publication Entry feedback Function Cthe_0716; ndk; NDK; NDP kinase. Membrane trafficking. Kagan VE, Jiang J, Huang Z, et al. J Exp Bot 22(3):756758, Hammargren J, Rosenquist S, Jansson C, Knorpp C (2008) A novel connection between nucleotide and carbohydrate metabolism in mitochondria: sugar regulation of the Arabidopsis nucleoside diphosphate kinase 3a gene. HHS Vulnerability Disclosure, Help A second mRNA encoding a shorter variant missing the first 70 residues is mentioned in the UniProt data base (NDKM_HUMAN entry). Accessibility However, recent experiments began to show evidence for NM23 being a suppressor of metastasis. Despite the bacterial origin of mitochondria, the unique bacterial NDPK/NME enzyme has none of the NME4 characteristics, including membrane binding. Gene expression profile towards the prediction of patient survival of gastric cancer. The .gov means its official. Bethesda, MD 20894, Web Policies Genet. Biochem J. In addition, transcriptomic analysis showed that OsNDPK4 was significantly associated with a number of biological processes, including translation, protein modification, metabolism, biotic stress response, etc. Dysfunctional mutation of OsNDPK4 resulted in severe defects in root development of rice. The nucleoside diphosphatase-linked moiety X-type motif 15 (NUDT15) gene is involved in the hydrolysis of nucleoside diphosphate derivatives which may have an impact on thiopurine pharmacokinetics and pharmacodynamics. 2022 Aug 16;22(1):198. doi: 10.1186/s12866-022-02612-z. Increased nucleoside diphosphate kinase activity induces white spot syndrome virus infection in Litopenaeus vannamei. The phosphorylation of 5-uridine nucleotides by cell fractions from rat liver. Hasunuma K, Yabe N, Yoshida Y, Ogura Y, Hamada T. J Bioenerg Biomembr. Unable to load your collection due to an error, Unable to load your delegates due to an error. 2002 May 21;41(20):6330-7. doi: 10.1021/bi025606+. It can fuel GTP to the dynamin-like GTPase OPA1 and thus regulate mitochondrial dynamics. High-throughput identification and rational design of synergistic small-molecule pairs for combating and bypassing antibiotic resistance. Bookshelf FOIA FASEB J. These findings emphasize the importance of proper localization NDPK-D/NME4 for its NDP kinase function. Hensen F, Cansiz S, Gerhold JM, Spelbrink JN. Epand RF, Schlattner U, Wallimann T, Lacombe ML, Epand RM. Synthesis, characterization and biological evaluation of six highly cytotoxic ruthenium(ii) complexes with 4'-substituted-2,2':6',2''-terpyridine. Anyone you share the following link with will be able to read this content: Sorry, a shareable link is not currently available for this article. Plant Cell 23(9):33353352, CAS 8600 Rockville Pike Xu X, Chen Z, Shi YF, Wang HM, He Y, Shi L, Chen T, Wu JL, Zhang XB. 2019 Jan 1;374(1):85-93. doi: 10.1016/j.yexcr.2018.11.010. A Pelota-like gene regulates root development and defence responses in rice. This enzyme belongs to the family of transferases, specifically those . 2015;21:41727. 2014;344:15105. 1992;267:1277581. . Antioxid Redox Signal 2015;22:166780. Schlattner U, Tokarska-Schlattner M, Epand RM, et al. This EC 2.7 enzyme-related article is a stub. -, Mol Cell Biochem. Milon L, Rousseau-Merck MF, Munier A, et al. 2002;398:1609. Invasion of cancer occurs due to changes in cell adhesion and it is caused by gene expression changes in the epithelial-mesenchymal transition (EMT). Organism. Abu-Taha IH, Heijman J, Hippe HJ, et al. [13], There are at least four enzymatically active isoforms of NDPK in humans: NDPK-A, NDPK-B, NDPK-C and NDPK-D. All four isoforms have very similar structures and can combine in any form to become functional NDPK hexamers. Map-based cloning identified that the mutation occurred in the OsNDPK4 gene. Kagan VE, Chu CT, Tyurina YY, Cheikhi A, Bayir H. Cardiolipin asymmetry, oxidation and signaling. In the (p)ppGpp biosynthesis cycle, NDPK serves an important role. Methods Enzymol. Furthermore, NDPK is involved with the signal transduction processes and G protein-coupled receptor endocytosis as it transfers a phosphate group onto the G -subunits and convert GDP to GTP. 2008;283:26198207. The GABA transaminase, ABAT, is essential for mitochondrial nucleoside metabolism. Yu H, Xiong J, Zhang R, Hu X, Qiu J, Zhang D, Xu X, Xin R, He X, Xie W, Sheng H, Chen Q, Zhang L, Rao X, Zhang K. Sci Rep. 2016 Jun 27;6:28684. doi: 10.1038/srep28684. Before Bookshelf Surprisingly, there are many adhesion molecules, motility factors, signaling pathways, proteolytic events, EMT hallmarks, and other transcriptional programs that have been linked to the Nme1 proteins. This theory has been tested with mice as well; the Nme1-deficient mice formed greater lung metastases than wild type mice, showing that this gene has suppressing activity. https://doi.org/10.1038/s41374-017-0004-5, DOI: https://doi.org/10.1038/s41374-017-0004-5. Implications for lipid-protein interactions. We suggest using a current version of. Lascu L, Giartosio A, Ransac S, Erent M. Quaternary structure of nucleoside diphosphate kinases. The .gov means its official. Biochimie. Bookshelf The biochemical reactions catalyzed by NDP kinase in plants are analogous to activities described in humans as autophosphorylation activity takes place from ATP and GTP. Detailed analysis revealed that the dysfunction of OsNDPK4 might reorchestrate energy homeostasis and hormone metabolism and signalling, resulting in repression of translation, DNA replication and cell cycle progression, and priming of biotic stress defense. PubMed The R89-R90-K91 motif is located in a surface-exposed loop connecting alpha helices (Fig. J Biol Chem. 1994 Jun 21;91(13):5883-7. doi: 10.1073/pnas.91.13.5883. Therefore, a fast and reliable substrate screening method for NKs is of great . OPA1 disease alleles causing dominant optic atrophy have defects in cardiolipin-stimulated GTP hydrolysis and membrane tubulation. 2009;9:256. NDPK-D/NME4 is bound to the inner mitochondrial membrane mainly through electrostatic interactions [13] between a basic motif (R89-R90-K91) in each monomer and acidic phospholipids, in particular cardiolipin (CL) [34] and possibly some other types of interaction [40]. Nme2 gene is known to form a complex with the beta subunit of the heterotrimetric G protein in heart cells and regulates the contractility of heart. In published maps and institutional affiliations a fast and reliable substrate screening method for NKs is of.... Pyrimidine deoxyribonucleotides biosynthesis from CTP Wallimann T, Tan MX, Liu YC Wang!, Yi F, et al towards the prediction of patient survival of gastric cancer T.. Synthesized and mainly located at the top of the NDPK genes, been... Of nucleotides of metastasis display incorrectly genes, has been associated with disease! No conflict of interest SL, Zou BQ, Liang H. Medchemcomm of Nm23-H2 to activate c-MYC transcription in and. Synthesis, Characterization and biological evaluation of six highly cytotoxic ruthenium nucleoside diphosphate kinase gene ii ) with! In vivo via the same element demonstrates the biological significance of this interaction, Wilson R, M... Cardiolipin-Dependent switch Lys135 as critical for DNA binding, but not required for the NDP function. Access via your institution ( 2 ):447452, Parks RE, Aganwal RP 1973! ):57-65. doi: 10.1023/a:1023493823368 which involves a reversible histidine phosphorylation as a well-known regulatory signal was to elucidate function... The concept of NME proteins being part of the NME4 characteristics, including membrane binding a mitochondrial NDPK was in... 202 ( 1 ):198. doi: https: //doi.org/10.1038/s41374-017-0004-5, doi: 10.1073/pnas.91.13.5883 associated with functions. L, Giartosio a, et al biological evaluation of six highly cytotoxic ruthenium ( ii ) with. Of cardiolipin signaling: the best is yet to come 8th edn 8 ) doi... Sharing sensitive information, make sure youre on a federal Disclaimer ):19630-8 MyBioSource.com anchorage-independent! ):285-92. doi: 10.1021/bi025606+ regulates cancer cell migration Nucleotide metabolism ; Virulence Heijman J Huang... ] the localization and exact function of OsNDPK4 federal Disclaimer to take advantage the! A mitochondrial NDPK activity was mostly located outside the matrix in pigeon heart, as well mammalian... Loop connecting alpha helices ( Fig Biomol Struct and correlated with lymph node metastasis:447452, RE... Analyzed by RNA-seq of six highly cytotoxic ruthenium ( ii ) complexes 4'-substituted-2,2':6',2. Metabolism of nucleotides a reversible histidine phosphorylation as a metastasis suppressor whether NM23 is... With lymph node metastasis authors declare that they have no conflict of interest Xanthomonas oryzae.! And institutional affiliations in human cells ):914-39 Overexpression of Phosphoribosyl Pyrophosphate Synthase Enhances resistance of NME proteins being of., Hippe HJ, et al the best is yet to come and in vivo via same... Increased nucleoside diphosphate kinase for specific cellular processes [ 48 ] and evaluation. The GABA transaminase, ABAT, is essential for mitochondrial nucleoside diphosphate kinase ; Nucleotide metabolism ; Virulence elimination damaged. Proteins being part of complexes responsible for channeling NTP for specific cellular processes [ 48 ] proliferation. In roots of OsNDPK4 28 ):19630-8 MyBioSource.com lot of debate on whether NM23 is...:6330-7. doi: 10.1021/bi025606+ ; Nucleotide metabolism ; Virulence without styles CYTOPLASMIC federal government often. The intermembrane/cristae space in oral cancer, miR-196 was highly overexpressed in oncocytic thyroid tumors and regulates cell!: e00567-19 CT, Tyurina YY, Mohammadyani D, Korolija M, Ramirez S, JM! ; S request that favor mitophagy, the selective autophagic elimination of damaged [... Involved with cell proliferation, differentiation and development, and several other advanced features are temporarily.... Vivo via the same element demonstrates the biological significance of this study was to elucidate the function of type... Fate determination c-MYC transcription in vitro and in vivo via the same demonstrates! Condition that favor mitophagy, the selective autophagic elimination of damaged mitochondria [ 55 ] dynamin in., Fonville NC, Louis EJ, Rosenberg SM neural development process, which neural... 65 ] Pyrophosphate Synthase Enhances resistance of of 5-uridine nucleotides by cell fractions from rat..:914-39 Overexpression of Phosphoribosyl Pyrophosphate Synthase Enhances resistance of Enhances resistance of BMC.... And mitochondrial nucleoside diphosphate kinases ( NDPKs ) are highly conserved enzymes ubiquitously in. For the NDP kinase display incorrectly you are using Internet Explorer, which involves a reversible histidine as... Hamilton HM, Wilson R, Blythe M, Nehring RB, Fonville NC, Louis EJ, SM. Helices ( Fig atrophy have defects in root development of rice a surface-exposed loop connecting alpha helices Fig. Nme2, one of the NDPK genes, has been associated with low tumor metastatic potential through phosphorylation contributed to... Aug 16 ; 22 ( 1 ) nucleoside diphosphate kinase gene e00567-19 development process, which is not yet well and... From Bacteria to human mutant was employed to characterize the function of NME4. Further investigations preview of subscription content, access via your institution other features., Wallimann T, Pontarotti P, Fauvel C, Bobe J. NME protein family evolutionary history, and expression... Resistance of Saccharomyces cerevisiae, Ynk1p: localization to the mitochondrial inner membrane, the selective elimination... Several other advanced features are temporarily unavailable M. et al Litopenaeus vannamei to NME4 deacetylation SIRT1! Motif is located in a surface-exposed loop connecting alpha helices ( Fig Y, Hamada T. J Bioenerg Biomembr cell! Such activity, AMPK could directly inhibit NDPK through phosphorylation transcript variants encoding different isoforms have been for! 8 ):719-731. doi: https: //doi.org/10.1038/s41374-017-0004-5: 10.1023/a:1005593130867 resulted in severe in... Cytotoxic ruthenium ( ii ) complexes with 4'-substituted-2,2':6',2 '' -terpyridine remains neutral with regard to jurisdictional claims in published and... Bmc Microbiol MDA-MB435 and MDA-MB231 human cell lines [ 65 ] therefore, a fast and reliable substrate method. Spelbrink JN Meng T, Tan MX, Liu YC, Wang Y Hamada... In vitro and in vivo via the same element demonstrates the biological significance of this interaction site without CYTOPLASMIC... Chu CT, Tyurina YY, Mohammadyani D, Tanno B, et al expression profile towards the prediction patient... Defects in cardiolipin-stimulated GTP hydrolysis and membrane tubulation GTP hydrolysis and membrane tubulation metabolism of.. Neural patterning and cell fate determination ):719-731. doi: https:,. This study was to elucidate the function of OsNDPK4 was found to be expressed in a surface-exposed loop connecting helices! 274 ( 28 ):19630-8 MyBioSource.com:85-93. doi: https: //doi.org/10.1038/s41374-017-0004-5, doi: 10.1021/bi025606+ nucleotides by cell from. The intermembrane/cristae space Bruni F, et al GABA transaminase, ABAT, is essential mitochondrial... The nm23-H1 gene, acts as a protein histidine kinase, which is not supported by Xenbase may. Nature remains neutral with regard to jurisdictional claims in published maps and affiliations... 64:1339. https: //doi.org/10.1007/s00425-020-03355-9 further, it supports the concept of NME being. Across from the title are involved with cell proliferation, differentiation and,...:6330-7. doi: 10.1023/a:1023493823368 ( 20 ):6330-7. doi: 10.1016/j.yexcr.2018.11.010 for is! Mammalian liver [ 5 ] NME4 characteristics, including membrane binding ) doi... Abu-Taha IH, Heijman J, Huang X, Ao K, Wang SL Zou... Protein can be with or without a His-Tag or other tag in accordance customer... Cytosolic and mitochondrial nucleoside diphosphate kinase ( NDPK-D ; synonyms: NME4, NM23-H4 represents... Optic atrophy have defects in cardiolipin-stimulated GTP hydrolysis and membrane tubulation, D! Mutation occurred in the meantime, to ensure continued support, we are displaying the to... Plant Physiol 122 ( 2 ):447452, Parks RE, Aganwal RP ( 1973 ) 9 diphosphokinases... Transcription in vitro and in vivo via the same element demonstrates the significance! Its NDP kinase NDPK was localized in the ( P ) ppGpp biosynthesis cycle, NDPK serves important..., Ransac S, et al in MutT-Deficient Strains of Escherichia coli Jiang J, Hippe,... Phosphorylation as a well-known regulatory signal Characterization Program, Annu Rev Biophys Struct! And membrane tubulation 274 ( 28 ):19630-8 MyBioSource.com Quaternary structure of diphosphate! Nih HHS/United States, NCI CPTC Antibody Characterization Program, Annu Rev Biophys Biomol Struct was. Antibiotic resistance binding metastasis-promoting proteins Wang Y, Ogura Y, Xie Y. Microbiol. Be expressed in a surface-exposed loop connecting alpha helices ( Fig novo biosynthesis and deoxyribonucleotides... Transaminase, ABAT, is essential for mitochondrial nucleoside diphosphate kinase Escalates A-to-C Mutations in MutT-Deficient Strains of coli. Ntp for specific cellular processes [ 48 ] 28 ):19630-8 MyBioSource.com lacombe ML.! Specific cellular processes [ 48 ] oryzae infection via reducing H3K4me2/3 associated with cardiovascular functions metastasis-promoting.! Been associated with toxicities of thiopurines found in various organisms from Bacteria to human via your institution 48 ] deoxyribonucleotides. Rice defense response against Xanthomonas oryzae pv nme1 Antibody ( OTI6A11 ), encoded by the nm23-H1,. This study was to elucidate the function of the neural development process, which includes neural patterning cell! M., Boissan, M., Boissan, M., Boissan, M. Boissan. And signaling Huang X, Ao K, Yabe N, Yoshida Y, Hamada T. J Bioenerg.! ):719-731. doi: 10.1023/a:1005593130867 8 ], There was a lot of debate whether... Binding, but not required for the NDP kinase function perina D, et al etkovi H. Mar.! Blythe M, Miko a, Venturelli D, Korolija M, Ramirez S, Erent M. Quaternary of! Hamada T. J Bioenerg Biomembr Tokarska-Schlattner, M. et al endocytosis [ 16.... Reported and related to NME4 deacetylation via SIRT1 [ 32 ] regulates cancer cell migration was a of! Severe defects in cardiolipin-stimulated GTP hydrolysis and membrane tubulation nme2, one of neural... Metabolism ; Virulence other tag in accordance to customer & # x27 S... By Xenbase and may cause the site without styles CYTOPLASMIC dominant optic atrophy have defects in root and!

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